After struggling away from home for nearly a year in the Champions League, Liverpool produced one of their most memorable away displays in the modern history of the competition by triumphing 3-1 against Bayern Munich at the Allianz Arena.
Not all the memories are bad for Man United, however.
This year is the 20th anniversary of United's treble-winning season, when they won the Premier League and FA Cup as well as the Champions League, with hard moments on the way to all three trophies.
FC Porto, who won the competition in 2004 under Jose Mourinho, are confident they can spring an upset after last year's mauling.
Jürgen Klopp's faith in the continued improvement of his Liverpool squad means he does not envisage spending big money on reinforcements this summer.
City have the greater depth and quality, plus the experience of being at this stage of the competition before, but Spurs are risky, and this tie could go all the way to penalties before we know who will face Ajax or Juventus in the semis.
Liverpool have won 17, drawn four and lost six of their 27 Premier League meetings with the Cottagers.
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Liverpool went on to thrash Los Blancos 4-0 at Anfield two weeks later to progress to the quarter finals.
"And that was maybe the main problem of Liverpool for the last decade".
However, after two brilliant goals from Mane and thumping Van Dijk header, the Reds had stunned the German champions away with a classic Liverpool performance in Europe, one which will be looked back in fondness for many years to come. "I could not be further away from thinking it's the best draw because it isn't".
Cristiano Ronaldo's hat-trick against Atletico Madrid kept Juventus' European dream alive.
United and Liverpool will meet in the semi-finals if they reach the last four, with Tottenham or Manchester City facing the victor of the quarter-final between Ajax and Juventus. Now they are just two, having broken into the Champions League places before their defeat to Arsenal.