Sane has still only started seven of City's 14 league games this season but four goals in his past five Premier League games suggests he is rediscovering his impressive form of the past two seasons.
"We have in mind the last minutes, (in) the last minutes anything could happen", said Guardiola.
'I trust in my club and my organisation and if something is wrong, they will tell us, ' he added.
The City manager, blessed with an embarrassment of riches in virtually every position, admits that team selection is one of the most hard aspects of his job.
"They are taller than us and stronger than us".
But against stronger opposition, perhaps in the Champions League, Guardiola will need Aguero fit and available because Jesus is now not good enough to play as a central-forward for this City team. "It didn't work because the first five or 10 minutes was like the first half".
But Guardiola believes the likes of the ex-Schalke star and fellow attacker Raheem Sterling can keep developing at City.
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Before Sterling's intervention, there was a growing sense in the Etihad that this could be the day City dropped points at home for the first time this season, fuelled by the threat Wilson and Joshua King were posing when Bournemouth broke forward.
"You always have chances, and we want to take advantage of the chances we have". "We had a good spell before half-time where we scored a good goal". Maybe in the future, it is going to help us to do what we're trying to do.
"After 0-2 we lost a little bit our control". "I thought the goals were scrappy from our perspective and avoidable".
Guardiola has not ruled De Bruyne, who has played just 81 minutes of league football this season due to two knee injuries, out of the weekend visit to Chelsea.
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"When I came to London I thought Big Ben was in the city but no, he is in Watford for us", said Watford manager Javi Gracia. "We didn't finish (this round) but we played today and tomorrow both or one of Arsenal and Tottenham will drop points".
Watford held firm, however, and their committed, physical approach to the game gave City numerous problems. Our success in the last 15 months is (because) we don't care too much about the other sides.
The champions appeared to be cruising towards the victory, but were made to fight for all three points after Abdoulaye Doucoure set up a nervy conclusion when he bundled the ball home for Watford with five minutes remaining.