The senator's comments come after Washington has repeatedly accused Russian Federation of meddling in the 2016 presidential election in order to influence the results of the vote in favour of then-Republican candidate Donald Trump.
Graham, a staunch ally of President Trump, has been critical of the probe.
"There are some that create more issues for us legally than others", Giuliani told the Washington Post.
Some 32 individuals and three Russian businesses have been indicted by Mueller and his team of prosecutors on charges ranging from computer hacking to obstruction of justice.
The Mueller investigation, which was launched in 2017 to look into these claims, has already led to a series of indictments.
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"They have found no collusion and have gone absolutely nuts".
"They are screaming and shouting at people, horribly threatening them to come up with answers they want". These are Angry People, including the highly conflicted Bob Mueller, who worked for Obama for 8 years.
Grassley brushed aside demands to hold a hearing on the ouster of former Attorney General Jeff Sessions and the designation of Matthew Whitaker as his acting replacement, saying Thursday that the law appears to have been followed.
Trump has always denied any such links and rejected the idea that Moscow played a significant role in influencing the dramatic election. He has also charged four Trump associates, although on counts not directly related to the alleged Russian interference.
"Last night, Senate Republicans blocked a bill to protect Mueller".
The top Democrats on the House and Senate judiciary committees and the House intelligence committee said in a joint statement that the opinion released on Wednesday twists the language of the U.S. Constitution and ignores an existing law governing succession at the Justice Department.
Publicly at least, Mueller's 18-month investigation was relatively quiet in the weeks leading up to the November 6 nation-wide congressional elections, partly because the Department of Justice tries to refrain from bringing politically sensitive cases forward around major elections.