Innovative drug extends breast cancer survival, study finds


Ten to 20 percent of breast cancers are called triple negative because they don't have receptors - such as ones for estrogen - that can be targeted by certain medications. The standard treatment is chemotherapy, to which most patients quickly develop resistance. It's approved for bladder and one type of lung cancer. Counselling should involve discussion about the diagnosis, adequate psychological and emotional support and various treatment options by the specialists in a sensitive and supportive environment. To help women take control of their health and continue the positive trend in survival rates, DHEC offers free breast cancer and cervical cancer screenings to qualified women through its Best Chance Network (BCN) program.

Side effects need a close look, both doctors said. Their discovery recently earned scientists a Nobel Prize. The research team was led by Fergus J. Couch, PhD, the Zbigniew and Anna M. Scheller Professor of Medical Research and Chair of the Division of Experimental Pathology and Laboratory Medicine at the Mayo Clinic. "Because I know that the triple negative is a type of cancer that is really hard to treat".

Until recently, BRCA1 was the only gene linked to TNBC. The Tecentriq-based combination also significantly reduced the risk of disease worsening or death (progression-free survival; PFS) compared to chemotherapy alone (median PFS=7.0 versus 5.5 months; HR=0.64; 95 percent CI: 0.54-0.77; p 0.0001) in the ITT-WT population.

"We used to check one gene at a time, which was very time consuming".

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"With incidence continuing to rise, and survival progress now stalling, we simply can not afford to let such clear chances to prevent thousands of deaths pass us by", said Baroness Morgan.

Researchers from Queen Mary University of London and St. Bartholomew Hospital have published a paper that shows how the combination of immunotherapy and chemotherapy can extend the lives of people with triple-negative breast cancer. And the company has been using its expertise to benefit breast cancer initiatives for well over a decade. They are: BARD1, BRCA1, BRCA2, PALB2, and RAD51D. Risk increases with age, having a personal or family history of breast, ovarian or prostate cancer, not having children before the age of 35 as well as not breastfeeding.

"Palbociclib is an innovative new drug that targets specific weaknesses in cancer cells, treating breast cancer in a smarter, kinder way than anything that had been available for these women before. I encourage women to be familiar with their own anatomy so that if they find something that's different or new, they're going to know that it's different because they've been checking themselves" Carolyn Haines, a nurse practitioner at the Nurse Managed Primary Care Center, says.