The man went with his wife to a trucking company in Bakersfield, California, where he shot and killed a man and then turned his gun on his spouse, killing her, Kern County Sheriff Donny Youngblood told a news conference.
"When the deputies responded, they located three victims of the shooting and the suspect had fled", said Lt King, adding that the man is believed to have shot two more victims at another location.
After the suspect was seen by a sheriff's deputy, the suspect reportedly pulled into a nearby parking lot and killed himself.
After a short foot chase the gunman shot and killed him too. However, authorities said they are still investigating the specific motive for the mass shooting.
The man shot dead his wife and four men in Bakersfield in Southern California.
After carjacking a vehicle, the woman and child inside managed to escape.
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He drove it to a nearby highway where he shot himself as police approached his vehicle. The husband at shot and killed his wife and the man. The confrontation was captured on the deputy's body camera. Youngblood did not disclose the identities of the victims.
There was no immediate word on what sparked the shootings that took place at a home and a business in Bakersfield, which is some 90 miles north of Los Angeles.
"It's very unusual to have six people killed in one incident", NBC quoted him as saying.
Authorities said it could take days to interview all witnesses and gather evidence from the multiple crime scenes.
Deputies are now interviewing about 30 people who witnessed the string of shootings.
Referring to recent shootings across the country, Youngblood decried Wednesday's events as the "new normal".