"There's no need to have a conversation", Johnson said Thursday on "Watch What Happens Live with Andy Cohen".
Fans have called on the Skyscraper actor to run for office following the publication of an article in The Washington Post two years ago which suggested that he could easily win an election.
"That whole thing with Tyrese, it was pretty disappointing because I've been friends with Tyrese for a very long time", he said.
When last year's "The Fate of the Furious" was wrapping production, Johnson called out his co-star Vin Diesel for being "unprofessional", and has recently implied that he still has ill-will toward Diesel. But seeing that Dwayne Johnson was in it meant that it was something I was interested in going along to see this as his recent releases have been quite entertaining.
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The 46-year old actor is now busy shooting for Disney's Jungle Cruise with co-star Emily Blunt. However, while on "Watch What Happens Live with Andy Cohen", Johnson would not confirm or list any unprofessional behavior, instead choosing to plead the fifth.
If you are looking to see Dwayne Johnson on the big screen soon be sure to see Skyscraper in theaters now and stay on the lookout for the Fast and Furious spinoff Hobbs & Shaw coming in 2019. There, Tyrese continued to direct responses at Johnson on social media.
"I love the idea of her doing it only because the wrestling business these days are a lot different than when I was there", Johnson said.
"So when that started picking up, of course, when I'm asked [I say] of course I have incredible respect for our American people and our country".
However, he was happy to address his past beef with WWE star John Cena, insisting thing are "so cool" between them.
Israel pounds Gaza in most violent daytime assault since 2014
The exchange of fire followed months of tension that raised the prospect of a fourth war in the blockaded Gaza Strip since 2008. The military had shut down a popular beach and placed limitations on gatherings of large crowds.
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What we learned today was that more members of the GRU, the Russian intelligence unit within their military, were involved. The Kremlin said no joint summit statement was planned but the presidents would give a news conference after their meeting.
Facebook respond to facing £500k fine over Cambridge Analytica scandal
And they will concerns for purchase personal information from "data intermediaries" to political parties. Any decisions here could lead to a maximum fine of 300,000 euros, he said.