Cavani scored both goals in Uruguay's 2-1 win on Saturday to set up a World Cup quarter final clash against France.
Edinson Cavani, who failed to finish the match after suffering a late injury, scored a superb goal in each half, and although Pepe scored in between, it was not enough to halt the Uruguayans, who have won all four of their matches so far in Russian Federation.
In the second half, Portugal was able to answer with a corner kick header from Pepe to tie things up and give Uruguay their first goal against since November 2017.
But Uruguay were back in front seven minutes later when Rodrigo Betancur allowed Cavani to brilliantly curl home his 45th global goal.
On the same day, Ronaldo and Lionel Messi exited the World Cup without having ever scored in the second round of the competition.
While Suarez seemed to play down or avoid questions about Ronaldo, it's clear Uruguay must continue to have the tightest defence in the tournament to keep Ronaldo and others under control.
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Portugal hasn't reached the World Cup quarterfinals since 2006, when a young Ronaldo led the team to the semifinals. Cavani, out deep on the right side, launched a crossfield pass for Luis Suarez on the left before receving back the high cross at the right post with a powerful header which beat goalminder Rui Patricio. The two players who have dominated the Ballon d'Or for a decade are now forced to take a backseat for the remainder of the greatest show on Earth.
That was the first goal the twice World Cup champions had conceded in the tournament in Russian Federation, but it took Cavani only seven minutes to put them back ahead at the packed Fisht Stadium overlooking the Black Sea.
The 32-year-old passed Uruguay's first test by saving Ronaldo's shot in the sixth minute.
There are many possible factors for Europe's grip on the World Cup, but South America's contribution to the world game is at least on a par with Europe, with so many of its players starring for European clubs.
Edinson Cavani latches onto the end of a Luis Suarez cross to nod in Uruguay's opener.
Uruguay had not conceded in any of their six matches in 2018 but almost 10 hours of resistance came to an end courtesy of a simple set-piece move in the 55th minute.